2016 Half-Day Gene Interaction camp

Computational Biology Research Camp for High School Students

Genetic interactions and regulations

miRcore-name

Overview: This camp introduces bioinformatics and computational modeling tools in the context of medical genomics. When you have genes of interest, what is the next step? Genomics is the study of genome which is the entirely of genes. We will explore how genes are related to each other using statistics and previously known biology. Lunch is included in the fee. Bring your laptops.

 

miRcore high school volunteers in the area have been founding GIDAS (pronounce: guide-us; Genes in Diseases and Symptoms) school club; this camp provides basic knowledge towards volunteer qualification.

 

DATE: March 12, 2015

LOCATION: Room 1670 Bob and Betty Beyster Building, University of Michigan, 2260 Hayward Street,  Ann Arbor, MI 48109

CAMP TIME: 9:30 am – 1:30 pm

FEE: $50

Online option available.

 

OPEN miRcore volunteer meeting

TIME: 2:00 pm – 3:00 pm

            All campers are invited to attend the following miRcore volunteer meeting for 2-3 pm in the same room.

 

Special Guest Lecture by Prof. Philip Maini (University of Oxford) at 2 pm

Title: Mathematics and Cancer

 

 

 

MAIN TARGETS: high school students (young women and men) who are interested in computer, math, biology, and medicine.

 

Sponsor: Women In Science and Engineering (WISE)

wiselogo


 

Registration

 

You will receive email confirmation of the registration and payment.


Payment options



 

Goals

  1. Expose high school students to the emerging era of medical genomics, when all doctors must be well-acquainted with genetic discoveries, technologies, and applications.
  2. Give high school students an opportunity to enjoy science. (Hear one student talking about it at TEDxYouth.)
  3. Support GIDAS (Genes In Diseases And Symptoms) club members in acquiring in-depth knowledge in the field.
  4. Encourage high school students to present at the 2016 Research Conference and publish an abstract.
  5. Encourage high school students to write a research paper in the Jounal of Emerging Investigators.
    1. Activated NF-κB Pathway in an Irf6-Deficient Mouse Model for Van der Woude Syndrome. Sanika S. Kulkarni(1), Jungwoo Chang(2), and Inhan Lee(3):(1) Pioneer High School, (2) Huron High School, (3) miRcore, Ann Arbor, MI.
    2. Transcriptional Regulators are Upregulated in the Substantia Nigra of Parkinson’s Disease Patients. Marianne Cowherd(1) and Inhan Lee(2): (1)Community High School, (2)miRcore, Ann Arbor, MI.

 

Tentative Agenda

9:30 am – 10:00 am Lung Cancer, DNA amplification, and expression changes
Identify list of genes related to lung cancer
Goal: understand consequences of specific DNA changes linked to lung cancer.
10:00 am – 10:30 am STRING-db
Protein-protein interaction prediction database
Goal: understand multiple interactions among genes
10:30 am- 11:00 am Gene Ontology
The framework of the model of biological system
Goal: be able to find gene ontology for a certain gene
11:00 am- 11:30 am Enrichment testing
Statistics to test enrichment in gene sets
Goal: understand the concept of enrichment testing
11:30 am – noon Grab lunch
noon – 12:30 pm Solve Problems

GO enrichment testing problems in lung cancer
Goal: explore problems her/his own way

12:30 pm – 1:00 pm KEGG pathway

Manually drawn maps representing our knowledge on the molecular interaction and reaction networks
Goal: understand activation and repression in gene-gene interaction

1:00 pm – 1:30 pm Make a new network hypothesis for lung cancer

Can additional gene be included in the known pathway?
Goal: generate own idea based on the data and known factors